Download File ->>> https://urllio.com/2sMJLT
the cns-ls consists of four subscale items: laughing and crying, as noted above, and attempts to laugh and cry, which were rated on a 7-point scale ranging from 0 (none) to 6 (severe). higher cns-ls scores indicate more frequent and severe pba episodes. the total score ranges from 0 to 42, with lower scores indicating less frequent and less severe pba episodes. the cns-ls has been validated in pba trials in als [ 20 ] and ms [ 23 ]. in this prism ii trial, the cns-ls showed high internal consistency reliability (α = 0.92 to α = 0.96) and test-retest reliability (r = 0.94 to r = 0.99). scores from the pba-q-16 were also correlated with the cns-ls (r = 0.59 to r = 0.73).efficacy was assessed on an intent-to-treat basis. the pba-q-16 was administered at baseline (day 1), at day 30 (visit 1), and at day 90 or early withdrawal (final visit). the pba-q-16 is a 16-item self-report measure that was developed to assess the frequency and severity of pba symptoms over the preceding 2 weeks [ 11 ]. item responses were rated on a 5-point scale ranging from 0 (not at all) to 4 (very much). higher pba-q-16 scores indicate more frequent and severe pba episodes. the pba-q-16 has been validated in studies of pba in patients with als and ms [ 11 19 ]. in this prism ii trial, the pba-q-16 showed high internal consistency reliability (α = 0.92 to α = 0.96) and test-retest reliability (r = 0.93 to r = 0.97).patient-reported outcomes were assessed at baseline (day 1), at day 30 (visit 1), and at day 90 or early withdrawal (final visit) to assess the efficacy of dm/q for pba. the patient global impression of change (pgic) is a 7-point scale ranging from “very much worse” to “very much better.” the patient rated their current overall impression of how the pba symptoms had been during the past 2 weeks. the pgic is a validated patient-rated instrument for measuring patient-reported change in pba symptoms [ 11 19 ].
98329e995e
https://open.firstory.me/story/cldnxbh8f0qga01tj2b3242in https://open.firstory.me/story/cldnxe1030dlz01t48zbkhxwv https://open.firstory.me/story/cldnxep050dm101t4b8yn5sal https://open.firstory.me/story/cldnxep050dm101t4b8yn5sal https://open.firstory.me/story/cldnxep050dm101t4b8yn5sal